| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Microplastics induce dose-specific transcriptomic disruptions in energy metabolism and immunity of the pearl oyster Pinctada margaritifera
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| Autores: |
Gardon, Tony
Morvan, Lucie
Huvet, Arnaud
Quillien, Virgile
Soyez, Claude
Le Moullac, Gilles
Le Luyer, Jeremy
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| Data: |
2020-11
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| Ano: |
2020
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| Palavras-chave: |
Microbeads
Marine bivalve
Differentially expressed genes
Stress response
Energy-limited tolerance
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| Resumo: |
A combined approach integrating bioenergetics and major biological activities is essential to properly understand the impact of microplastics (MP) on marine organisms. Following experimental exposure of polystyrene microbeads (micro-PS of 6 and 10 μm) at 0.25, 2.5, and 25 μg L−1, which demonstrated a dose-dependent decrease of energy balance in the pearl oyster Pinctada margaritifera, a transcriptomic study was conducted on mantle tissue. Transcriptomic data helped us to decipher the molecular mechanisms involved in P. margaritifera responses to micro-PS and search more broadly for effects on energetically expensive maintenance functions. Genes related to the detoxification process were impacted by long-term micro-PS exposure through a decrease in antioxidant response functioning, most likely leading to oxidative stress and damage, especially at higher micro-PS doses. The immune response was also found to be dose-specific, with a stress-related activity stimulated by the lowest dose present after a 2-month exposure period. This stress response was not observed following exposure to higher doses, reflecting an energy-limited capacity of pearl oysters to cope with prolonged stress and a dramatic shift to adjust to pessimum conditions, mostly limited and hampered by a lowered energetic budget. This preliminary experiment lays the foundation for exploring pathways and gene expression in P. margaritifera, and marine mollusks in general, under MP exposure. We also propose a conceptual framework to properly assess realistic MP effects on organisms and population resilience in future investigations.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
https://archimer.ifremer.fr/doc/00640/75213/75351.pdf
https://archimer.ifremer.fr/doc/00640/75213/75352.docx
DOI:10.1016/j.envpol.2020.115180
https://archimer.ifremer.fr/doc/00640/75213/
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| Editor: |
Elsevier BV
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| Formato: |
application/pdf
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| Fonte: |
Environmental Pollution (0269-7491) (Elsevier BV), 2020-11 , Vol. 266 , N. Part 3 , P. 115180 (9p.)
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| Direitos: |
info:eu-repo/semantics/openAccess
restricted use
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